MilbemaxTab Cats + 2kg Internal Vermifuge Broad Spectrum 2 Tablets is a treatment for mixed infestations with immature and adult stages of the following cestodes and nematodes:
Cestodes: Dipylidium caninum, Taenia spp, Echinococcus multilocularis.
Nematodes: Ancylostoma tubaeforme, Toxocara cati.
Pharmacodynamic properties :
Milbemycin belongs to the macrocyclic lactone family, produced by fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, larval and adult stages of nematodes, and larvae of Dirofilaria immitis. It acts on nerve transmission in invertebrates: milbemycin oxime, like avermectins and other milbemycins, potentiates the permeability of nematode and insect membranes to chloride ions via glutamate-chloride channels (linked to GABAA and glycine receptors). This causes hyperpolarization of the neuromuscular membrane, leading to flaccid paralysis and death of the parasite.
Praziquantel is an acyl derivative of pyrazinoisoquinoline. It is active against cestodes and trematodes. Praziquantel acts by altering the permeability of parasite membranes to calcium (Ca2+ influx), thus deregulating membrane equilibrium. This results in depolarization of the membrane, followed by instant muscle contraction (tetany), rapid vacuolization of the tegumental syncytium and disintegration of the tegument, facilitating excretion through the gastrointestinal tract, or death of the parasite.
Pharmacokinetic characteristics :
In cats, praziquantel has a peak plasma concentration within one hour of oral administration. The half-life is approximately 3 hours.
After oral administration in cats, milbemycin shows a peak plasma concentration within 2 hours. Elimination half-life is around 13 hours (± 9 hours).
Directions for use
The minimum recommended dose is 2 mg of milbemycin oxime per kg of body weight and 5 mg of praziquantel per kg of body weight, in a single oral dose.
The speciality should be administered during or after meals, to ensure optimum protection against heartworm disease.
Depending on the cat's weight, the dose to be administered is as follows:
Weight Number of tablets
2 - 4 kg ½ tablet
> 4 - 8 kg 1 tablet
> 8 - 12 kg 1 ½ tablets
The drug can be integrated into a heartworm prevention program, if concomitant treatment against cestodes is indicated. Monthly administration of this speciality will help prevent heartworm disease. For continuous prevention of heartworm disease, it is preferable to use a single substance.
Precautions for use :
Warnings specific to each target species:
In order to develop an effective worm control program, local epidemiological data and the risk of cat exposure must be taken into account.
It is recommended to treat all animals living in the same household at the same time.
When infestation with the cestode D. caninum is confirmed, concomitant treatment against intermediate hosts, such as fleas and lice, should be discussed with the veterinarian to prevent re-infestation.
Special precautions for use in animals:
In accordance with good veterinary practice, animals should be weighed before administration to ensure appropriate dosage.
Ensure that cats and kittens weighing between 0.5 and 2 kg receive the appropriate dosage tablet (4 mg milbemycin oxime / 10 mg praziquantel) and the appropriate dose (1/2 or 1 tablet) for the corresponding weight range (1/2 tablet for cats weighing from 0.5 kg to 1 kg; 1 tablet for cats weighing over 1 and up to 2 kg).
Echinococcosis presents a potential risk for humans. In the event of Echinococcosis, specific treatment, follow-up and personal safety protocols must be followed. Consult an expert or a parasitology center.
No trials have been carried out on severely debilitated cats or those with significant kidney or liver damage. In such cases, use of the product is not recommended, or only after assessment of the benefit/risk ratio by a veterinarian.
Special precautions to be taken by the person administering the veterinary drug to animals:
Wash hands after use.
In the event of accidental ingestion of tablets, particularly by children, seek medical advice and show the box and/or leaflet.
Undesirable effects (frequency and severity):
In very rare cases, particularly in young cats, hypersensitivity reactions, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as vomiting and diarrhoea) have been observed after administration of the veterinary drug.
The frequency of adverse reactions is defined as follows:
- very frequent (adverse reactions occurring in more than 1 in 10 animals treated).
- frequent (between 1 and 10 animals out of 100 treated).
- uncommon (between 1 and 10 animals out of 1,000 treated).
- rare (between 1 and 10 animals out of 10,000 treated animals).
- very rare (less than 1 in 10,000 animals treated, including isolated cases).
Use during pregnancy and lactation:
The drug may be used in breeding cats, including those in gestation or lactation.
Drug interactions and other forms of interaction :
Concomitant administration with selamectin is well tolerated.
No interactions have been observed when a macrocyclic lactone, such as selamectin, is administered at the recommended dose.
Although not recommended, concomitant use of the speciality with a spot on containing moxidectin and imidacloprid at the recommended doses in a single application was well tolerated in a laboratory study involving 10 kittens.
The safety and efficacy of concomitant use have not been evaluated in field trials. In the absence of other studies, particular care should be taken when concomitantly administering the product with any other macrocyclic lactone. In addition, no studies of this type have been carried out on breeding animals.
Overdosage :
In the event of overdosage, in addition to the signs observed at the recommended dose (see "Adverse reactions (frequency and severity)"), hypersalivation may be observed. This sign generally disappears spontaneously during the day.
Composition MilbemaxTab Cats + 2kg Internal Vermifuge Large Spectrum 2 Tablets
List of excipients :
Microcrystalline cellulose.
Croscarmellose sodium.
Povidone.
Lactose monohydrate.
Colloidal anhydrous silica.
Magnesium stearate.
Red iron oxide (E 172).
Artificial beef flavor.
Hypromellose.
Macrogol 8000.
Talcum powder.
For 1 132.5 mg scored tablet:
Milbemycin oxime: 16 mg
Praziquantel: 40 mg.
Red iron oxide (E172): 0.288 mg
MilbemaxTab Cats + 2kg Internal Vermifuge Broad Spectrum 2 Tablets is a treatment for mixed infestations with immature and adult stages of the following cestodes and nematodes:
Cestodes: Dipylidium caninum, Taenia spp, Echinococcus multilocularis.
Nematodes: Ancylostoma tubaeforme, Toxocara cati.
Pharmacodynamic properties :
Milbemycin belongs to the macrocyclic lactone family, produced by fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, larval and adult stages of nematodes, and larvae of Dirofilaria immitis. It acts on nerve transmission in invertebrates: milbemycin oxime, like avermectins and other milbemycins, potentiates the permeability of nematode and insect membranes to chloride ions via glutamate-chloride channels (linked to GABAA and glycine receptors). This causes hyperpolarization of the neuromuscular membrane, leading to flaccid paralysis and death of the parasite.
Praziquantel is an acyl derivative of pyrazinoisoquinoline. It is active against cestodes and trematodes. Praziquantel acts by altering the permeability of parasite membranes to calcium (Ca2+ influx), thus deregulating membrane equilibrium. This results in depolarization of the membrane, followed by instant muscle contraction (tetany), rapid vacuolization of the tegumental syncytium and disintegration of the tegument, facilitating excretion through the gastrointestinal tract, or death of the parasite.
Pharmacokinetic characteristics :
In cats, praziquantel has a peak plasma concentration within one hour of oral administration. The half-life is approximately 3 hours.
After oral administration in cats, milbemycin shows a peak plasma concentration within 2 hours. Elimination half-life is around 13 hours (± 9 hours).
Directions for use
The minimum recommended dose is 2 mg of milbemycin oxime per kg of body weight and 5 mg of praziquantel per kg of body weight, in a single oral dose.
The speciality should be administered during or after meals, to ensure optimum protection against heartworm disease.
Depending on the cat's weight, the dose to be administered is as follows:
Weight Number of tablets
2 - 4 kg ½ tablet
> 4 - 8 kg 1 tablet
> 8 - 12 kg 1 ½ tablets
The drug can be integrated into a heartworm prevention program, if concomitant treatment against cestodes is indicated. Monthly administration of this speciality will help prevent heartworm disease. For continuous prevention of heartworm disease, it is preferable to use a single substance.
Precautions for use :
Warnings specific to each target species:
In order to develop an effective worm control program, local epidemiological data and the risk of cat exposure must be taken into account.
It is recommended to treat all animals living in the same household at the same time.
When infestation with the cestode D. caninum is confirmed, concomitant treatment against intermediate hosts, such as fleas and lice, should be discussed with the veterinarian to prevent re-infestation.
Special precautions for use in animals:
In accordance with good veterinary practice, animals should be weighed before administration to ensure appropriate dosage.
Ensure that cats and kittens weighing between 0.5 and 2 kg receive the appropriate dosage tablet (4 mg milbemycin oxime / 10 mg praziquantel) and the appropriate dose (1/2 or 1 tablet) for the corresponding weight range (1/2 tablet for cats weighing from 0.5 kg to 1 kg; 1 tablet for cats weighing over 1 and up to 2 kg).
Echinococcosis is a potential risk for humans. In the event of Echinococcosis, specific treatment, follow-up and personal safety protocols must be followed. Consult an expert or a parasitology center.
No trials have been carried out on severely debilitated cats or those with significant kidney or liver damage. In such cases, use of the product is not recommended, or only after evaluation of the benefit/risk ratio by a veterinarian.
Special precautions to be taken by the person administering the veterinary drug to animals:
Wash hands after use.
In the event of accidental ingestion of tablets, particularly by children, seek medical advice and show the box and/or leaflet.
Undesirable effects (frequency and severity):
In very rare cases, particularly in young cats, hypersensitivity reactions, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as vomiting and diarrhoea) have been observed after administration of the veterinary drug.
The frequency of adverse reactions is defined as follows:
- very frequent (adverse reactions occurring in more than 1 in 10 animals treated).
- frequent (between 1 and 10 animals out of 100 treated).
- uncommon (between 1 and 10 animals out of 1,000 treated).
- rare (between 1 and 10 animals out of 10,000 treated animals).
- very rare (less than 1 in 10,000 animals treated, including isolated cases).
Use during pregnancy and lactation:
The drug may be used in breeding cats, including those in gestation or lactation.
Drug interactions and other forms of interaction :
Concomitant administration with selamectin is well tolerated.
No interactions have been observed when a macrocyclic lactone, such as selamectin, is administered at the recommended dose.
Although not recommended, concomitant use of the speciality with a spot on containing moxidectin and imidacloprid at the recommended doses in a single application was well tolerated in a laboratory study involving 10 kittens.
The safety and efficacy of concomitant use have not been evaluated in field trials. In the absence of other studies, particular care should be taken when concomitantly administering the product with any other macrocyclic lactone. In addition, no studies of this type have been carried out on breeding animals.
Overdosage :
In the event of overdosage, in addition to the signs observed at the recommended dose (see "Adverse reactions (frequency and severity)"), hypersalivation may be observed. This sign generally disappears spontaneously during the day.
Composition MilbemaxTab Cats + 2kg Internal Vermifuge Large Spectrum 2 Tablets
List of excipients :
Microcrystalline cellulose.
Croscarmellose sodium.
Povidone.
Lactose monohydrate.
Colloidal anhydrous silica.
Magnesium stearate.
Red iron oxide (E 172).
Artificial beef flavor.
Hypromellose.
Macrogol 8000.
Talcum powder.
For 1 132.5 mg scored tablet:
Milbemycin oxime: 16 mg
Praziquantel: 40 mg.
Red iron oxide (E172): 0.288 mg
MilbemaxTab Cats + 2kg Internal Vermifuge Broad Spectrum 2 Tablets is a treatment for mixed infestations with immature and adult stages of the following cestodes and nematodes:
Cestodes: Dipylidium caninum, Taenia spp, Echinococcus multilocularis.
Nematodes: Ancylostoma tubaeforme, Toxocara cati.
Pharmacodynamic properties :
Milbemycin belongs to the macrocyclic lactone family, produced by fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, larval and adult stages of nematodes, and larvae of Dirofilaria immitis. It acts on nerve transmission in invertebrates: milbemycin oxime, like avermectins and other milbemycins, potentiates the permeability of nematode and insect membranes to chloride ions via glutamate-chloride channels (linked to GABAA and glycine receptors). This causes hyperpolarization of the neuromuscular membrane, leading to flaccid paralysis and death of the parasite.
Praziquantel is an acyl derivative of pyrazinoisoquinoline. It is active against cestodes and trematodes. Praziquantel acts by altering the permeability of parasite membranes to calcium (Ca2+ influx), thus deregulating membrane equilibrium. This results in depolarization of the membrane, followed by instant muscle contraction (tetany), rapid vacuolization of the tegumental syncytium and disintegration of the tegument, facilitating excretion through the gastrointestinal tract, or death of the parasite.
Pharmacokinetic characteristics :
In cats, praziquantel has a peak plasma concentration within one hour of oral administration. The half-life is approximately 3 hours.
After oral administration in cats, milbemycin shows a peak plasma concentration within 2 hours. Elimination half-life is around 13 hours (± 9 hours).
Directions for use
The minimum recommended dose is 2 mg milbemycin oxime per kg bodyweight and 5 mg praziquantel per kg bodyweight, in a single oral dose.
The speciality should be administered during or after meals, to ensure optimum protection against heartworm disease.
Depending on the cat's weight, the dose to be administered is as follows:
Weight Number of tablets
2 - 4 kg ½ tablet
> 4 - 8 kg 1 tablet
> 8 - 12 kg 1 ½ tablets
The drug can be integrated into a heartworm prevention program, if concomitant treatment against cestodes is indicated. Monthly administration of this speciality will help prevent heartworm disease. For continuous prevention of heartworm disease, it is preferable to use a single substance.
Precautions for use :
Warnings specific to each target species:
In order to develop an effective worm control program, local epidemiological data and the risk of cat exposure must be taken into account.
It is recommended to treat all animals living in the same household at the same time.
When infestation with the cestode D. caninum is confirmed, concomitant treatment against intermediate hosts, such as fleas and lice, should be discussed with the veterinarian to prevent re-infestation.
Special precautions for use in animals:
In accordance with good veterinary practice, animals should be weighed before administration to ensure appropriate dosage.
Ensure that cats and kittens weighing between 0.5 and 2 kg receive the appropriate dosage tablet (4 mg milbemycin oxime / 10 mg praziquantel) and the appropriate dose (1/2 or 1 tablet) for the corresponding weight range (1/2 tablet for cats weighing from 0.5 kg to 1 kg; 1 tablet for cats weighing over 1 and up to 2 kg).
Echinococcosis is a potential risk for humans. In the event of Echinococcosis, specific treatment, follow-up and personal safety protocols must be followed. Consult an expert or a parasitology center.
No trials have been carried out on severely debilitated cats or those with significant kidney or liver damage. In such cases, use of the product is not recommended, or only after evaluation of the benefit/risk ratio by a veterinarian.
Special precautions to be taken by the person administering the veterinary drug to animals:
Wash hands after use.
In the event of accidental ingestion of tablets, particularly by children, seek medical advice and show the box and/or leaflet.
Undesirable effects (frequency and severity):
In very rare cases, particularly in young cats, hypersensitivity reactions, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as vomiting and diarrhoea) have been observed after administration of the veterinary drug.
The frequency of adverse reactions is defined as follows:
- very frequent (adverse reactions occurring in more than 1 in 10 animals treated).
- frequent (between 1 and 10 animals out of 100 treated).
- uncommon (between 1 and 10 animals out of 1,000 treated).
- rare (between 1 and 10 animals out of 10,000 treated animals).
- very rare (less than 1 in 10,000 animals treated, including isolated cases).
Use during pregnancy and lactation:
The drug may be used in breeding cats, including those in gestation or lactation.
Drug interactions and other forms of interaction :
Concomitant administration with selamectin is well tolerated.
No interactions have been observed when a macrocyclic lactone, such as selamectin, is administered at the recommended dose.
Although not recommended, concomitant use of the speciality with a spot on containing moxidectin and imidacloprid at the recommended doses in a single application was well tolerated in a laboratory study involving 10 kittens.
The safety and efficacy of concomitant use have not been evaluated in field trials. In the absence of other studies, particular care should be taken when concomitantly administering the product with any other macrocyclic lactone. In addition, no studies of this type have been carried out on breeding animals.
Overdosage :
In the event of overdosage, in addition to the signs observed at the recommended dose (see "Adverse reactions (frequency and severity)"), hypersalivation may be observed. This sign generally disappears spontaneously during the day.
Composition MilbemaxTab Cats + 2kg Internal Vermifuge Large Spectrum 2 Tablets
List of excipients :
Microcrystalline cellulose.
Croscarmellose sodium.
Povidone.
Lactose monohydrate.
Colloidal anhydrous silica.
Magnesium stearate.
Red iron oxide (E 172).
Artificial beef flavor.
Hypromellose.
Macrogol 8000.
Talcum powder.
For 1 132.5 mg scored tablet:
Milbemycin oxime: 16 mg
Praziquantel: 40 mg.
Red iron oxide (E172): 0.288 mg
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